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Dominion 6.6 in Osaka-jo Hall was an professional wrestling event promoted by New Japan Pro-Wrestling (NJPW). The event took place on June 7, 2021, in Osaka, Osaka, at the Osaka-jō Hall and is the thirteen event under the Dominion name and sixth in a row to take place at the Osaka-jō Hall. The event was originally planned to take place on June 6, but was postponed to the following day due to the state of emergency in Japan because of the COVID-19 pandemic, although the name of the event was not changed. In the main event, Shingo Takagi fought Kazuchika Okada for the vacant IWGP World Heavyweight Championship. In other prominent matches, Jeff Cobb battled Kota Ibushi, and Yoh challenged El Desperado for the IWGP Junior Heavyweight Championship.