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On New Year's Eve 1900, Paul Holzgruber started a new praxis as a radiologist. The young Maximiliane Frey is his assistant and they have worked side by side for years helping people. Holzgruber repeatedly points out the dangers of radiation to Maximiliane, but is silent about the ulcers on his hand and the severe pain they have caused. Maximiliane has gotten to know the widower Axel von Bonin and has fallen in love with him. But then she is diagnosed with incurable cancer. To spare Axel the inevitable grief over her impending death, she leaves him and dedicates what is left her life to medicine.