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ONE Fight Night 25: Nicolas vs. Eersel 2 was a combat sport event produced by ONE Championship that took place on October 5, 2024, at Lumpinee Boxing Stadium in Bangkok, Thailand. A ONE Lightweight Kickboxing World Championship rematch between current champion Alexis Nicolas and former champion (also current ONE Lightweight Muay Thai World Champion) Regian Eersel headlined the event. They previously met at ONE Fight Night 21 in April 2024, where Nicolas won the title by unanimous decision.